Edward Cone, Ph.D.

Drug Delivery and Abuse Deterrent Drug Products

Ed Cone is recognized world-wide for his expertise on the chemistry and pharmacology of drugs of abuse. At PinneyAssociates, he consults on the evaluation of abuse-deterrent formulations and development of novel drug delivery systems, based on his knowledge of pharmacokinetics and drug testing methodologies.

Throughout his career, Ed has emphasized the value of applying real-world experience to solve problems in the laboratory. Doing just that, his practical model for in vitro laboratory assessment of abuse-deterrence predicted much of what appears in the 2015 FDA Guidance on Abuse-Deterrent Opioids — Evaluation and Labeling. He has presented in meetings with the FDA reviewing divisions and Advisory Committees on behalf of numerous pharmaceutical clients.

At the Addiction Research Center of the National Institute on Drug Abuse, Ed completed a series of seminal studies on the metabolism and excretion of opioid agonists and antagonists. As Chief of the Chemistry Section, he was responsible for executing a variety of clinical studies concerning the pharmacokinetics and pharmacodynamics of psychoactive drugs.

He has extensive experience in the design and execution of clinical research studies and has trained six doctoral candidates. Ed has published over 250 research and review articles and chapters on a broad array of topics concerning human drug administration.

He has been a member of the Johns Hopkins University School of Medicine faculty since 1998 and is presently Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences.

  • Cited by Science Watch as the most highly cited author in forensic science over the period of 1981-1993
  • Awarded the Irvine Sunshine Award in Clinical Toxicology, “In Recognition of Pioneering Work in Clinical Toxicology” (1995), at the International Association of Therapeutic Drug Monitoring and Clinical Toxicology meeting
  • Recognized as the Scientist Professional Advisory Committee Career Scientist of the Year Award by the US Public Health Service Commissioned Officer’s Association (1996), “To acknowledge an exemplary career of pioneering research on the detection of psychoactive drugs in human and for the broad implication of discoveries to improve drug abuse prevention and treatment”
  • Received the Rolla Harger Award from the American Academy of Forensic Sciences for “Outstanding Contributions to Forensic Toxicology” (2000)
  • Received the Irvine Alan Curry Award for his extensive research in Clinical Toxicology from the International Association of Forensic Toxicologists (2006)