The Abuse Potential of 7-Hydroxymitragynine (7-OH) According to the 8 Factors of the Controlled Substances Act

The present document provides an 8-FA of 7-OH according to the 1970 Controlled Substances Act. This  has been developed following the model laid out in FDA’s guidance, Assessment of the Abuse Potential of Drugs, while also taking into consideration the experience and evolution in approach to such assessments since the CSA was signed into law in 1970. The present analysis considered and expands upon the pharmacological and epidemiological data that were presented in FDA’s July 29, 2025 scientific assessment and incorporates insights from prior work by Pinney Associates, including the 2018 and 2022 kratom 8-FAs and related analyses.

Read more